Lancome Visionnaire Advanced Skin Corrector- Press release


INVENTING THE FUTURE…..



“From the beginning, Lancôme has consistently written the story of cosmetics in an ever more increasingly visionary
spirit.

Visionary is a word that defines the conception of Lancôme’s skincare better than any other.

Skincare that is always ahead of its time, both from a scientific point of view but also in its understanding of
women’s needs and desires…

Women’s desires change, as does their vision of beauty. But their desire to look simply beautiful, whatever their age,
remains.

Thus, VISIONNAIRE [LR 2412 4%] Advanced Skin Corrector is created. A global skincare solution based on a
unique molecule with optimal tolerance.



 
The beautiful skin molecule is born. The dream of a flawless skin. The perfection of VISIONNAIRE [LR 2412
4%].”

Youcef Nabi,
Lancôme Worldwide President

SKINCARE A HEAD OF ITS TIME

Lancôme innovates with VISIONNAIRE [LR 2412 4%], its first skincare product formulated to fundamentally
recreate truly beautiful skin.

A Lancôme technological breakthrough has identified a miraculous new molecule.

The name of this molecule: LR 2412. A molecule that is able to “self-propel” through the layers
of the epidermis, to set off a series of tissular micro-transformations.

The result is that skin is visibly transformed: the texture is finer, wrinkles are erased, pigmentary and vascular
irregularities are reduced and pores are tightened.

THE NEW VISION OF BEAUTY

WOMEN ARE BECOMING MORE DYNAMIC, MORE ATTRACTIVE, WHATEVER THEIR AGE, AND
THEIR SKIN NEEDS TO REFLECT THIS.



The question is no longer whether their skin betrays age but rather that it reflects how women feel deep inside, their
energy and quest for perfection, both in their professional and personal lives.

Far more than simply fighting against wrinkles and their visible age, they long for a truly beautiful skin quality:
smoother, plumper, free of pigmentation and vascular irregularities.

Quite simply, truly beautiful skin.

To achieve this, women today know that targeted action is no longer enough. Whether at the dermatologists or at
home, they are looking for a multitude of ways to lead them to perfection.

For that, today’s woman needs a variety of solutions to achieve perfect skin and they want results to see visible
changes.

WOMEN ARE CHANGING. LANCÔME ANTICIPATES THEIR DESIRES.

A MOLECULE WITH A VISIONARY DESIGN

LR 2412
MOLECULE LR 2412 IS THE RESULT OF 10 YEARS OF RESEARCH AND ITS CREATION AT THE
FOREFRONT OF TECHNOLOGY IS PROTECTED BY 17 PATENTS.

INSPIRED BY NATURE


The best inventions are often inspired by observing nature, and our Researchers have always been interested in the
processes that the plant world uses to repair itself.
Their objective? To identify new substances, which could inspire them in actively treating the skin.
When plants are damaged they produce a “signal-molecule” called jasmonic acid. This activates the healing of the
damaged tissues, and also serves to make them more resistant. Within plants, it is this “signal-molecule” that triggers
the action of repair and defense mechanisms.

JASMONIC ACID, A “SIGNAL-MOLECULE” FOR A PLANTS’ DEFENCE AND HEALING PROCESSES
When a plant is attacked, it synthesizes jasmonic acid from the linolenic acid of its cellular membranes. Then the
jasmonic acid activates the transcription of encoding genes for the synthesis of repair and defense proteins that
makes the plant more resistant to future attacks.

A SOURCING PROCESS THAT RESPECTS THE ENVIRONMENT ESTABLISHING A CUSTOM-BUILT
MODEL


Our Research challenge: mimic the jasmonic acid’s repairing ability in a compound that’s in perfect affinity with
human skin. Our Research created and studied around 20 derivatives of this substance over a period of more than 10
years. Out of these studies, the molecule identified as LR 2412, was born.

AN EXCLUSIVE SOURCING METHOD


LR 2412 is produced using a process of development and optimisation which took 2 years to develop.
Developed as an environmentally friendly way to create the formula, a rare metal is used as a catalyst agent,
allowing the process to take place in one single stage. It is called HydrogénèseTM “in one pot”.

Eco-designed, it reveals a nature-friendly efficiency:
• Atom Economy: 77%
• Synthesis process performance: 98%
• Very favourable E-Factor (environmental factor):

Footprint The footprint highlights the aim of taking into account environmental impact.
Each criteria is marked from 1 (very favourable) to 4 (less favourable).

[H2O] Water Consumption

[iL] Locality index for raw materials
Highlights the reduction of CO2 discharges or of the resources used for the transport of raw materials.

[eFA] Re-evaluation of water effluent

[slOS] Re-evaluation of solvents

[artC ] Re-evaluation of packaging materials

[eVS] Efficiency of the synthesis route
Takes the number of operations and the global production of the synthesis into consideration.

[eF] E-factor: environmental factor
This index represents the waste mass produced per kg of finished product.


[txC] Renewable carbon rate

[ieMP] Potential environmental impact of raw materials

[iePF] Potential environmental impact of finished product

LR 2412
AN OMNIPRESENT MOLECULE A UNIVERSAL MOLECULE ABLE TO PERMEATE ALL
LAYERS OF THE SKIN

A UNIQUE MOLECULAR DESIGN


LR 2412 is designed to “self-propel” throughout all areas of the skin. A universal molecule with an ability to
permeate through all layers of the skin.

The key to this incredible permeating ability is its amphiphilic nature. LR 2412 shows an affinity for both aqueous
and lipid structures. From the first contact, it fuses with the skin, then “propels” itself into all of the layers. Through
the permeation of all the skin’s compartments, its strength is diffused to the deepest layers.

LR 2412
DIFFUSION THROUGH ALL STRATA OF THE SKIN
PENETRATION STUDIES EX VIVO, ON SKIN EXPLANTS

After having crossed the stratum corneum, LR 2412 sinks through both the epidermis and the dermis. This
molecule is 4 times more bio available than a lipophilic reference molecule like retinol.

A SERIES OF MICRO -TRANSFORMATIONS IN ALL AREAS OF THE SKIN

Just like in plants, LR 2412 behaves like a “signal-molecule” in the skin. During its diffusion through the skin,
LR 2412 sets off chain reactions* in all the skin’s layers, targeting the key factors leading to the renewal of the skin’s
material.

LR 2412 boosts the synthesis of fundamental elements of the skin*, among which are the key components of
hyaluronasome. Hyaluronasome is the sum of the molecules involved in the synthesis (hyaluronan synthase HAS),
the maturation (hyaluronidase) and the fixation of the hyaluronic acid on the specific receptors (CD44v3).

EPIDERMIS: FOR A REINVIGORATED REGENERATION

LR 2412 STIMULATES, IN A TARGETED WAY, THE PRODUCTION OF 6 KEY MARKERS* OF THE
EPIDERMAL STRUCTURE AND REGENERATION.

These 6 markers are Ki67, keratin K5, epidermal thickness, syndecan and components of epidermal hyaluronasome:
hyaluronan synthase HAS3 and receptors CD44v3 , attesting to a regenerated and reorganized epidermis. The
efficiency is illustrated in the photos below:

LR 2412 ACCELERATES EPIDERMIS REGENERATION.


When LR 2412 is applied to an area of the skin where the superficial layers have been eliminated, it is observed that
the repair of the tissues is perceptible from the 7th day** with LR 2412, compared to the untreated area. In addition,
the barrier function of the skin is improved.
** Double Blind Test in vivo, 2% of LR 2412 against placebo, 28 people

LR 2412 RESPECTS THE EPIDERMIS*.
It doesn’t disturb the expression of the epidermal différentiation markers* (keratin K10, transglutaminase TG1 and filaggrin).
* In Vitro Tests

DERMO-EPIDERMAL JUNCTION: FOR BETTER “CONNECTED” SKIN COMPARTMENTS

In this critical area of support for the skin, LR 2412 increases* the synthesis of 3 key markers: collagen IV, collagen
VII and laminine 332 (formerly called laminine 5), essential constituents of a well-structured dermo-epidermal
junction.

DERMIS: FOR A RESTRUCTURED SKIN MATTRESS*
LR 2412 has a stimulating action on the synthesis of the key markers of the dermis* and notably the pro-collagen
I, forerunner of collagen I, known as “young” and predominantly present in the skin. It acts on the synthesis of
fibrillin, a fibril of elastin which is a major component of the superficial dermis, playing on the “spring” of the skin.
* In Vitro Tests

At the same time, LR 2412 increases* by a factor of 2 the expression of a component of hyaluronan synthase: HAS2.
* In Vitro Tests

LR 2412,
AN IN VIVO PERFORMANCE DEMONSTRATED
BY PROFESSOR GRIFFITH, AN INDEPENDENT EXPERT,
ACCORDING TO A RECOGNIZED STUDY PROTOCOL

Applied under an occlusive patch over 12 days, LR 2412 demonstrates in vivo a stimulating activity on the
synthesis of fibrillin equivalent to that of retinol, considered as the reference active molecule on this parameter.

A biological response was observed in 100% of subjects who participated in the study**.
** Clinical study on 14 subjects

A FUSIONAL TEXTURE

A CUSTOMIZED FORMULA

The formula was developed around the specific qualities of LR 2412, so as to display all its effectiveness and
optimize the global performance of VISIONNAIRE [LR 2412 4%].

A UNIQUE POLYSENSORIALITY


Its texture fuses with the skin and instantly permeates it. From application, the skin is transformed under the fingers:
enveloped in a voluptuous sensation, it appears soft, silky and supple.
The refined fragrance of VISIONNAIRE [LR 2412 4%] combines the freshness of the rose, as a modern and light
top note, with precious flowers delivering the sophisticated notes to create an original scent.

TESTED ON ALL COMPLEXIONS

The VISIONNAIRE [LR 2412 4%] performance has been tested on different complexions: Hispanic, Caucasian,
Asian and Afro-American.

A TOLERANCE WITHOUT COMPROMISE


VISIONNAIRE [LR 2412 4%] can be used on all skin types, even on sensitive skin and on the eye contour – all year
round, morning and night.

A LUXURIOUS HIGH-TECH DESIGN


The future is taking shape. Luxury is reinventing itself. VISIONNAIRE [LR 2412 4%] is its best expression.
The bottle draws its inspiration from a high-technology mix of glass and metal. A fusion of silver and malachite
green, as if crossed by a laser beam.
The spirit of an era looking towards the avant-garde. The quintessence of the most visionary design…

TWO COMPLEMENTARY SKINCARE FORMULAS FOR PERFECT SKIN


A genuine technological breakthrough, these 2 Lancôme serums were designed to respond to the most demanding
women’s desire for a perfect skin.

GÉNIFIQUE Youth Activating Concentrate was a Lancôme skincare beauty first. It boosts* the activity of the
genes for a visibly rejuvenated skin.

Powerful and effective, VISIONNAIRE [LR 2412 4%] is the first Advanced Skin Corrector for wrinkles, pores and
even skin tone, which fundamentally recreates truly beautiful skin.
* Proteomic Study – 24 women – 8 weeks

In the VISIONNAIRE[ LR2412 4%] advertising campaign, Lancôme offers a new vision of perfection.
The focus is on the faces of women from different origins (Hispanic, Caucasian, African and Asian). Their skin
shows the benefits of VISIONNAIRE [LR2412 4%] Advanced Skin Corrector, for the first time
and in a tangible way.